InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Higd1a

Summary

InnateDB Protein

IDBP-205729.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Higd1a

Protein Name

HIG1 domain family, member 1A

Synonyms

2210020B17Rik; 7420700H20Rik; AI303276; AW049839; Hig1; HIMP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054881

InnateDB Gene

IDBG-205727 (Higd1a)

Protein Structure

UniProt Annotation

Function

Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion membrane {ECO:0000255PROSITE- ProRule:PRU00836}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00836}. Mitochondrion inner membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0042149	cellular response to glucose starvation
GO:0043066	negative regulation of apoptotic process
GO:0055114	oxidation-reduction process
GO:0071456	cellular response to hypoxia
GO:0090201	negative regulation of release of cytochrome c from mitochondria

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043234	protein complex
GO:0070469	respiratory chain