InnateDB Protein
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IDBP-205827.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cops6
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Protein Name
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COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)
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Synonyms
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Sgn3; VIP/MOV34;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000019638
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InnateDB Gene
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IDBG-205825 (Cops6)
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Protein Structure
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Function |
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor- responsive activity (By similarity). Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets, including SFN (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 272 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
272 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1349439
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InterPro |
IPR000555
JAB1/MPN/MOV34 metalloenzyme domain
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PFAM |
PF01398
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PRINTS |
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PIRSF |
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SMART |
SM00232
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TIGRFAMs |
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Modification |
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SwissProt |
O88545
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PhosphoSite |
PhosphoSite-O88545
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TrEMBL |
Q3UIT2
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UniProt Splice Variant |
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Entrez Gene |
26893
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UniGene |
Mm.3981
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RefSeq |
NP_036132
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MGI ID |
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MGI Symbol |
Cops6
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OMIM |
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CCDS |
CCDS19792
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HPRD |
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IMGT |
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EMBL |
AC151719
AF071315
AK146775
BC004664
BC014286
CH466529
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GenPept |
AAC33902
AAH04664
AAH14286
BAE27424
EDL19216
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