Version 5.4
| Mus musculus Protein: Ap4m1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-205893.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Ap4m1 | ||||||||
| Protein Name | adaptor-related protein complex AP-4, mu 1 | ||||||||
| Synonyms | 4930443L05Rik; Ap4m4; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000019662 | ||||||||
| InnateDB Gene | IDBG-205891 (Ap4m1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal- lysosomal system. Plays a role in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits amyloidogenic processing of APP (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Golgi apparatus, trans-Golgi network {ECO:0000250}. Membrane, coated pit {ECO:0000250}. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells (By similarity). {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1337063 | ||||||||
| InterPro |
IPR001392
Clathrin adaptor, mu subunit IPR008968 Clathrin adaptor, mu subunit, C-terminal IPR011012 Longin-like domain IPR022775 AP complex, mu/sigma subunit IPR028565 Mu homology domain |
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| PFAM |
PF00928
PF01217 |
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| PRINTS |
PR00314
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| PIRSF |
PIRSF005992
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| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9JKC7 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | Q2TFN8 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 11781 | ||||||||
| UniGene | Mm.113205 | ||||||||
| RefSeq | NP_067367 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Ap4m1 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS19794 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF242858 AY912459 AY912460 AY912461 AY912462 AY912463 AY912464 AY912465 AY912466 AY912467 AY912468 AY912469 AY912470 AY912471 AY912472 AY912473 AY912474 AY912475 AY912476 AY912477 AY912478 AY912479 AY912480 AY912481 BC011174 | ||||||||
| GenPept | AAF63513 AAH11174 AAW83718 AAW83719 AAW83720 AAW83721 AAW83722 AAW83723 AAW83724 AAW83725 AAW83726 AAW83727 AAW83728 AAW83729 AAW83730 AAW83731 AAW83732 AAW83733 AAW83734 AAW83735 AAW83736 AAW83737 AAW83738 AAW83739 AAW83740 | ||||||||