Version 5.4
Mus musculus Protein: Ric3
Summary
InnateDB Protein IDBP-206085.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ric3
Protein Name resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000056990
InnateDB Gene IDBG-206083 (Ric3)
Protein Structure
UniProt Annotation
Function Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5- HT3 receptors, and of heteromeric acetylcholine receptors alpha- 3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. {ECO:0000269PubMed:19812337}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:19812337}; Single-pass membrane protein {ECO:0000269PubMed:19812337}.
Disease Associations
Tissue Specificity Expressed in brain, with highest levels in hippocampus, cerebellum and superior colliculus. {ECO:0000269PubMed:12821669}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0033130 acetylcholine receptor binding
GO:0044183 protein binding involved in protein folding
Biological Process
GO:0006457 protein folding
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007271 synaptic transmission, cholinergic
GO:0043623 cellular protein complex assembly
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2443887
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BPM6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 320360
UniGene Mm.71007
RefSeq NP_848895
MGI ID
MGI Symbol Ric3
OMIM
CCDS CCDS21733
HPRD
IMGT
EMBL AK053760 AK082275 AK149334 BC059258
GenPept AAH59258 BAC35510 BAC38452 BAE28817

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca