InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snrpb

Summary

InnateDB Protein

IDBP-206171.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snrpb

Protein Name

small nuclear ribonucleoprotein B

Synonyms

AL024368; AU018828; SM-B; SM11; SMB; SNRNP-B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099488

InnateDB Gene

IDBG-206169 (Snrpb)

Protein Structure

UniProt Annotation

Function

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. {ECO:0000269PubMed:19470752}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0071208	histone pre-mRNA DCP binding

Biological Process

GO:0000387

spliceosomal snRNP assembly

Cellular Component

GO:0005634	nucleus
GO:0005683	U7 snRNP
GO:0005685	U1 snRNP
GO:0005687	U4 snRNP
GO:0005689	U12-type spliceosomal complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0034709	methylosome
GO:0034719	SMN-Sm protein complex
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome
GO:0071204	histone pre-mRNA 3'end processing complex

Protein Structure and Domains

PDB ID

MGI:98342

InterPro

IPR001163 Ribonucleoprotein LSM domain
IPR006649 Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920 Like-Sm (LSM) domain
IPR017131 Small ribonucleoprotein associated, SmB/SmN

PFAM

PF01423

PRINTS

PIRSF

PIRSF037187

SMART

SM00651

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt