InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fh1

Summary

InnateDB Protein

IDBP-206421.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fh1

Protein Name

fumarate hydratase 1

Synonyms

Fh; Fh-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027810

InnateDB Gene

IDBG-206419 (Fh1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Isoform Mitochondrial: Mitochondrion.Isoform Cytoplasmic: Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004333	fumarate hydratase activity
GO:0016829	lyase activity

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006106	fumarate metabolic process
GO:0048873	homeostasis of number of cells within a tissue

Cellular Component

GO:0005739	mitochondrion
GO:0045239	tricarboxylic acid cycle enzyme complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95530

InterPro

IPR000362 Fumarate lyase family
IPR005677 Fumarate hydratase, class II
IPR008948 L-Aspartase-like
IPR018951 Fumarase C, C-terminal
IPR022761 Fumarate lyase, N-terminal

PFAM

PF10415
PF00206

PRINTS

PR00149

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97807