InnateDB Protein
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IDBP-206737.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nphp4
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Protein Name
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nephronophthisis 4 (juvenile) homolog (human)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000049920
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InnateDB Gene
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IDBG-206731 (Nphp4)
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Protein Structure
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Function |
Involved in the organization of apical junctions in kidney cells, together with NPHP1 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. {ECO:0000269PubMed:21565611}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Note=In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 216 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
216
[view]
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Protein-Protein |
216
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2384210
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P59240
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PhosphoSite |
PhosphoSite-P59240
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TrEMBL |
Q80UJ2
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UniProt Splice Variant |
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Entrez Gene |
260305
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UniGene |
Mm.439281
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RefSeq |
XP_006538930
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MGI ID |
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MGI Symbol |
Nphp4
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OMIM |
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CCDS |
CCDS38985
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HPRD |
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IMGT |
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EMBL |
AL607109
AL611970
AY118229
BC044732
BC138370
CH466594
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GenPept |
AAH44732
AAI38371
AAM78559
CAM21853
CAM23668
EDL14939
EDL14940
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