InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Brip1

Summary

InnateDB Protein

IDBP-206743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Brip1

Protein Name

BRCA1 interacting protein C-terminal helicase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043108

InnateDB Gene

IDBG-206741 (Brip1)

Protein Structure

UniProt Annotation

Function

DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the 'Fanconi anemia' pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

MGI:2442836

InterPro

IPR006554 Helicase-like, DEXD box c2 type
IPR006555 ATP-dependent helicase, C-terminal
IPR010614 DEAD2
IPR013020 DNA helicase (DNA repair), Rad3 type
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014013 Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF13307
PF06733

PRINTS

PIRSF

SMART

SM00488
SM00491
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5SXJ3