InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hnrnpu

Summary

InnateDB Protein

IDBP-206840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnrnpu

Protein Name

heterogeneous nuclear ribonucleoprotein U

Synonyms

AA408410; AI256620; AL024194; AL024437; AW557595; C86794; hnRNP U; Hnrpu; SAFA; Sp120;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047571

InnateDB Gene

IDBG-206838 (Hnrnpu)

Protein Structure

UniProt Annotation

Function

Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell surface {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Also found associated with the cell surface (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 216 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	216 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0070934	CRD-mediated mRNA stabilization

Cellular Component

GO:0009986	cell surface
GO:0070937	CRD-mediated mRNA stability complex
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

MGI:1858195

InterPro

IPR001870 B30.2/SPRY domain
IPR003034 SAP domain
IPR003877 SPla/RYanodine receptor SPRY
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR010488 Zeta toxin domain
IPR018355 SPla/RYanodine receptor subgroup
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02037
PF00622
PF06414

PRINTS

PIRSF

SMART

SM00513
SM00449

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VEK3