InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ahctf1

Summary

InnateDB Protein

IDBP-206971.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ahctf1

Protein Name

AT hook containing transcription factor 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027768

InnateDB Gene

IDBG-206969 (Ahctf1)

Protein Structure

UniProt Annotation

Function

Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis (By similarity). Has also been proposed to function as a transcription factor which may play a specific role in hematopoietic tissues (PubMed:11952839). {ECO:0000250, ECO:0000269PubMed:11952839}.

Subcellular Localization

Chromosome, centromere, kinetochore {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nuclear pore complex. Nucleus matrix. Cytoplasm. Note=Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107-160 subcomplex of the NPC. Localizes to the periphery of chromatin from late anaphase (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with higher expression in testis, lung and kidney. Expressed in T-cells, B-cells and granulocytes in bone marrow. {ECO:0000269PubMed:11952839}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000910	cytokinesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007067	mitotic nuclear division
GO:0015031	protein transport
GO:0030097	hemopoiesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051028	mRNA transport
GO:0051292	nuclear pore complex assembly

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016363	nuclear matrix
GO:0031080	nuclear pore outer ring
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome