InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Parva

Summary

InnateDB Protein

IDBP-206986.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Parva

Protein Name

parvin, alpha

Synonyms

2010012A22Rik; 5430400F08Rik; Actp; AI225929; AU042898; CH-ILKBP; Parvin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033030

InnateDB Gene

IDBG-206984 (Parva)

Protein Structure

UniProt Annotation

Function

Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. {ECO:0000269PubMed:11134073, ECO:0000269PubMed:19798050}.

Subcellular Localization

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0002040	sprouting angiogenesis
GO:0003148	outflow tract septum morphogenesis
GO:0007155	cell adhesion
GO:0007163	establishment or maintenance of cell polarity
GO:0008360	regulation of cell shape
GO:0031532	actin cytoskeleton reorganization
GO:0034113	heterotypic cell-cell adhesion
GO:0034446	substrate adhesion-dependent cell spreading
GO:0060271	cilium morphogenesis
GO:0070252	actin-mediated cell contraction
GO:0071670	smooth muscle cell chemotaxis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0030018	Z disc
GO:0030027	lamellipodium