InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cltc

Summary

InnateDB Protein

IDBP-207021.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cltc

Protein Name

clathrin, heavy polypeptide (Hc)

Synonyms

3110065L21Rik; CHC; R74732;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099475

InnateDB Gene

IDBG-207019 (Cltc)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 135 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	135 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0005198	structural molecule activity
GO:0005488	binding
GO:0032051	clathrin light chain binding

Biological Process

GO:0006886	intracellular protein transport
GO:0016192	vesicle-mediated transport
GO:0031623	receptor internalization
GO:0033572	transferrin transport
GO:0045087	innate immune response (InnateDB)
GO:0090307	spindle assembly involved in mitosis
GO:1900126	negative regulation of hyaluronan biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005819	spindle
GO:0030117	membrane coat
GO:0030130	clathrin coat of trans-Golgi network vesicle
GO:0030132	clathrin coat of coated pit
GO:0031523	Myb complex
GO:0042470	melanosome
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0071439	clathrin complex

Protein Structure and Domains

PDB ID

MGI:2388633

InterPro

IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
IPR001473 Clathrin, heavy chain, propeller, N-terminal
IPR015348 Clathrin, heavy chain, linker, core motif
IPR016024 Armadillo-type fold
IPR016341 Clathrin, heavy chain
IPR022365 Clathrin, heavy chain, propeller repeat

PFAM

PF00637
PF09268
PF01394

PRINTS

PIRSF

PIRSF002290

SMART

SM00299

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt