Version 5.4
Mus musculus Protein: Cltc
Summary
InnateDB Protein IDBP-207023.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Cltc
Protein Name clathrin, heavy polypeptide (Hc)
Synonyms 3110065L21Rik; CHC; R74732;
Species Mus musculus
Ensembl Protein ENSMUSP00000050220
InnateDB Gene IDBG-207019 (Cltc)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 135 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 135 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0005198 structural molecule activity
GO:0005488 binding
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
GO:0045087 innate immune response (InnateDB)
GO:0090307 spindle assembly involved in mitosis
Cellular Component
GO:0005739 mitochondrion
GO:0030117 membrane coat
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit
GO:0031523 Myb complex
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:2388633
InterPro IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
IPR001473 Clathrin, heavy chain, propeller, N-terminal
IPR015348 Clathrin, heavy chain, linker, core motif
IPR016024 Armadillo-type fold
IPR016341 Clathrin, heavy chain
IPR022365 Clathrin, heavy chain, propeller repeat
PFAM PF00637
PF09268
PF01394
PRINTS
PIRSF PIRSF002290
SMART SM00299
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8K2I5
UniProt Splice Variant
Entrez Gene 67300
UniGene Mm.479526
RefSeq
MGI ID
MGI Symbol Cltc
OMIM
CCDS
HPRD
IMGT
EMBL AK143503 AL592222 BC031408
GenPept AAH31408 BAE25402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca