InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Parp1

Summary

InnateDB Protein

IDBP-207196.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Parp1

Protein Name

poly (ADP-ribose) polymerase family, member 1

Synonyms

5830444G22Rik; Adprp; Adprt1; AI893648; ARTD1; C80510; PARP; parp-1; PPOL; sPARP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027777

InnateDB Gene

IDBG-207194 (Parp1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 186 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	186 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding
GO:0051287	NAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000723	telomere maintenance
GO:0006259	DNA metabolic process
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006302	double-strand break repair
GO:0006471	protein ADP-ribosylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0016540	protein autoprocessing
GO:0023019	signal transduction involved in regulation of gene expression
GO:0032869	cellular response to insulin stimulus
GO:0040009	regulation of growth rate
GO:0042769	DNA damage response, detection of DNA damage
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060391	positive regulation of SMAD protein import into nucleus
GO:0070212	protein poly-ADP-ribosylation
GO:2000679	positive regulation of transcription regulatory region DNA binding

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0016020	membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:1340806

InterPro

IPR001357 BRCT domain
IPR001510 Zinc finger, PARP-type
IPR004102 Poly(ADP-ribose) polymerase, regulatory domain
IPR008288 NAD+ ADP-ribosyltransferase
IPR008893 WGR domain
IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
IPR012982 PADR1

PFAM