InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psma1

Summary

InnateDB Protein

IDBP-207215.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psma1

Protein Name

proteasome (prosome, macropain) subunit, alpha type 1

Synonyms

alpha-type; C2; HC2; Pros-30;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033008

InnateDB Gene

IDBG-207213 (Psma1)

Protein Structure

UniProt Annotation

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal macrophage proteasome. Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells. {ECO:0000269PubMed:12874245, ECO:0000269PubMed:19526544, ECO:0000269PubMed:22341445}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Detected in liver (at protein level). {ECO:0000269PubMed:22341445}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 106 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	106 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0004175	endopeptidase activity
GO:0004298	threonine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0002376	immune system process
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005839	proteasome core complex
GO:0019773	proteasome core complex, alpha-subunit complex