InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxk1

Summary

InnateDB Protein

IDBP-207231.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxk1

Protein Name

forkhead box K1

Synonyms

A630048H08Rik; AI463295; ENSMUSG00000075577; Gm10868; Mnf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072616

InnateDB Gene

IDBG-207227 (Foxk1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli. {ECO:0000269PubMed:8007964, ECO:0000269PubMed:9271401}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in tissues and cells in which the myoglobin gene is transcriptionally active including cardiac and skeletal myocytes, brain and kidney. In the adult brain, expressed in the piriform cortex and the indusium griseum. In the hippocampus, expression is localized to the dentate gyrus and CA3 area. In the cerebellum, expression is confined to the Purkinje cell layer. {ECO:0000269PubMed:16376864, ECO:0000269PubMed:8007964, ECO:0000269PubMed:9271401}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008301	DNA binding, bending
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0007517	muscle organ development
GO:0009888	tissue development
GO:0030154	cell differentiation
GO:0030308	negative regulation of cell growth
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated