InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc23a2

Summary

InnateDB Protein

IDBP-207252.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc23a2

Protein Name

solute carrier family 23 (nucleobase transporters), member 2

Synonyms

AI844736; mKIAA0238; NBTL1; Slc23a1; SVCT2; YSPL2; YSPL3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028815

InnateDB Gene

IDBG-207250 (Slc23a2)

Protein Structure

UniProt Annotation

Function

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein.

Disease Associations

Note=Elevated expression levels in the adrenals of diabetic mice. {ECO:0000269PubMed:17689499}.

Tissue Specificity

Expressed in metabolically active and specialized tissues, including high expression in brain and adrenals. Detected in a wide range of tissues. Expression in kidney is almost undetectable. {ECO:0000269PubMed:17689499}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008520	L-ascorbate:sodium symporter activity
GO:0015229	L-ascorbic acid transporter activity
GO:0070890	sodium-dependent L-ascorbate transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006814	sodium ion transport
GO:0006979	response to oxidative stress
GO:0015882	L-ascorbic acid transport
GO:0019852	L-ascorbic acid metabolic process
GO:0035461	vitamin transmembrane transport
GO:0055085	transmembrane transport
GO:0070904	transepithelial L-ascorbic acid transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane