Version 5.4
Mus musculus Protein: Mtmr4
Summary
InnateDB Protein IDBP-207497.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mtmr4
Protein Name myotubularin related protein 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000099468
InnateDB Gene IDBG-207495 (Mtmr4)
Protein Structure
UniProt Annotation
Function Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized to perinuclear region. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:2180699
InterPro IPR000306 FYVE zinc finger
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR010569 Myotubularin-like phosphatase domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF01363
PF06602
PRINTS
PIRSF
SMART SM00064
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91XS1
PhosphoSite PhosphoSite-Q91XS1
TrEMBL A7M7R1
UniProt Splice Variant
Entrez Gene 170749
UniGene Mm.489088
RefSeq NP_573478
MGI ID
MGI Symbol Mtmr4
OMIM
CCDS CCDS25214
HPRD
IMGT
EMBL AF262986 AK146641 AL596086
GenPept AAK58180 BAE27324 CAI35136 CAI35138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca