Version 5.4
Mus musculus Protein: Capn8
Summary
InnateDB Protein IDBP-207747.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Capn8
Protein Name calpain 8
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000047164
InnateDB Gene IDBG-207745 (Capn8)
Protein Structure
UniProt Annotation
Function Calcium-regulated non-lysosomal thiol-protease (By similarity). Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex. {ECO:0000250, ECO:0000269PubMed:16476741}.
Subcellular Localization Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000269PubMed:16476741}.
Disease Associations
Tissue Specificity Predominantly expressed in the stomach. Localizes strictly to the surface mucus cells in the gastric epithelium and the mucus-secreting goblet cells in the duodenum. {ECO:0000269PubMed:11523006, ECO:0000269PubMed:16476741}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID MGI:2181366
InterPro IPR001300 Peptidase C2, calpain, catalytic domain
IPR022682 Peptidase C2, calpain, large subunit, domain III
IPR022683 Peptidase C2, calpain, domain III
IPR022684 Peptidase C2, calpain family
PFAM PF00648
PF01067
PRINTS PR00704
PIRSF
SMART SM00230
SM00720
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91VA3
PhosphoSite PhosphoSite-Q91VA3
TrEMBL
UniProt Splice Variant
Entrez Gene 170725
UniGene Mm.189201
RefSeq NP_570960
MGI ID
MGI Symbol Capn8
OMIM
CCDS CCDS35814
HPRD
IMGT
EMBL AB050201 AB050202 AB050203 AB061518 AB061519 BC125504 BC125508
GenPept AAI25505 AAI25509 BAB55000 BAB55001 BAB70479 BAB70480 BAB70481

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca