InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hlx

Summary

InnateDB Protein

IDBP-207841.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hlx

Protein Name

H2.0-like homeobox

Synonyms

Hlx1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040505

InnateDB Gene

IDBG-207839 (Hlx)

Protein Structure

UniProt Annotation

Function

Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis. {ECO:0000269PubMed:12055627}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in Th1 cells, CD8-positive T-cells, B-cells and NK cells. {ECO:0000269PubMed:12055627}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001889	liver development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007519	skeletal muscle tissue development
GO:0008284	positive regulation of cell proliferation
GO:0030154	cell differentiation
GO:0045627	positive regulation of T-helper 1 cell differentiation
GO:0045629	negative regulation of T-helper 2 cell differentiation
GO:0046622	positive regulation of organ growth
GO:0048484	enteric nervous system development
GO:0048513	organ development
GO:0048557	embryonic digestive tract morphogenesis