InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vwa1

Summary

InnateDB Protein

IDBP-207864.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vwa1

Protein Name

von Willebrand factor A domain containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040405

InnateDB Gene

IDBG-207862 (Vwa1)

Protein Structure

UniProt Annotation

Function

Promotes matrix assembly. {ECO:0000269PubMed:18757743}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269PubMed:12062410, ECO:0000269PubMed:16407285, ECO:0000269PubMed:18757743}.

Disease Associations

Tissue Specificity

Expressed at high levels in the chondrocytes. Detected in the vasculature of neural tissues, in basement membrane structures of the peripheral nervous system, in the apical ectodermal ridge of developing limb buds, and in skeletal and cardiac muscle (at protein level). {ECO:0000269PubMed:12062410, ECO:0000269PubMed:18314316}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0030198	extracellular matrix organization
GO:0048266	behavioral response to pain

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005614	interstitial matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome