Version 5.4
Mus musculus Protein: Gpr139
Summary
InnateDB Protein IDBP-207894.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpr139
Protein Name G protein-coupled receptor 139
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000081700
InnateDB Gene IDBG-207892 (Gpr139)
Protein Structure
UniProt Annotation
Function Orphan receptor. Seems to act through a G(q/11)-mediated pathway.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed almost exclusively in the brain. Abundantly expressed in the ventrolateral region of caudate putamen, the habenular nucleus, the zona incerta, and the medial mammillary nucleus. {ECO:0000269PubMed:15845401}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0008188 neuropeptide receptor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2685341
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80UC8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 209776
UniGene Mm.300632
RefSeq NP_001019309
MGI ID
MGI Symbol Gpr139
OMIM
CCDS CCDS21778
HPRD
IMGT
EMBL AB196532 AY255548 BC125496 BC125498
GenPept AAI25497 AAI25499 AAO85060 BAD97443

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca