InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Jag1

Summary

InnateDB Protein

IDBP-207936.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jag1

Protein Name

jagged 1

Synonyms

ABE2; Gsfabe2; Htu; Ozz; Ser-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028735

InnateDB Gene

IDBG-207934 (Jag1)

Protein Structure

UniProt Annotation

Function

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis. {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Widely expressed in many tissues, with highest expression in brain, heart, muscle and thymus. {ECO:0000269PubMed:10556292}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	4 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001974	blood vessel remodeling
GO:0002011	morphogenesis of an epithelial sheet
GO:0002456	T cell mediated immunity
GO:0003184	pulmonary valve morphogenesis
GO:0003215	cardiac right ventricle morphogenesis
GO:0007154	cell communication
GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0009887	organ morphogenesis
GO:0032495	response to muramyl dipeptide
GO:0035909	aorta morphogenesis
GO:0042491	auditory receptor cell differentiation
GO:0043010	camera-type eye development
GO:0045596	negative regulation of cell differentiation
GO:0045599	negative regulation of fat cell differentiation
GO:0045639	positive regulation of myeloid cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048839	inner ear development
GO:0060411	cardiac septum morphogenesis
GO:0061073	ciliary body morphogenesis
GO:0061156	pulmonary artery morphogenesis
GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061314	Notch signaling involved in heart development
GO:0061444	endocardial cushion cell development
GO:0072017	distal tubule development
GO:0072070	loop of Henle development
GO:0097150	neuronal stem cell maintenance
GO:2000737	negative regulation of stem cell differentiation

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:1095416

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001007 von Willebrand factor, type C
IPR001774 Delta/Serrate/lag-2 (DSL) protein
IPR001881 EGF-like calcium-binding domain
IPR006552 VWC out
IPR011651 Notch ligand, N-terminal
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF00093
PF01414
PF07645
PF07657
PF07974

PRINTS

PIRSF

SMART

SM00181
SM00214
SM00051
SM00179
SM00215

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QXX0