InnateDB Protein
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IDBP-207972.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Aimp2
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Protein Name
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aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000031613
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InnateDB Gene
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IDBG-207968 (Aimp2)
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Protein Structure
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Function |
Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269PubMed:12060739, ECO:0000269PubMed:12819782, ECO:0000269PubMed:16135753, ECO:0000269PubMed:18695251}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:18695251}. Nucleus {ECO:0000269PubMed:18695251}. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
51 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2385237
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InterPro |
IPR010987
Glutathione S-transferase, C-terminal-like
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R010
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PhosphoSite |
PhosphoSite-Q8R010
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
231872
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UniGene |
Mm.200499
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RefSeq |
NP_001165617
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MGI ID |
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MGI Symbol |
Aimp2
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OMIM |
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CCDS |
CCDS51692
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HPRD |
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IMGT |
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EMBL |
AC121917
AC166900
BC024410
BC026958
BC026972
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GenPept |
AAH24410
AAH26958
AAH26972
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