Version 5.4
Mus musculus Protein: Btbd3
Summary
InnateDB Protein IDBP-207980.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Btbd3
Protein Name BTB (POZ) domain containing 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000074864
InnateDB Gene IDBG-207976 (Btbd3)
Protein Structure
UniProt Annotation
Function Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed. {ECO:0000269PubMed:24179155}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:24179155}. Nucleus {ECO:0000269PubMed:24179155}. Note=Translocates from the cytosol to the nucleus in response to neuronal activity.
Disease Associations
Tissue Specificity In the somatosensory cortex, specifically expressed in spiny stellate neurons during barrel formation. Also expressed in the olfactory bulb, piriform cortex and hippocampus. {ECO:0000269PubMed:24179155}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0021987 cerebral cortex development
GO:0048813 dendrite morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:2385155
InterPro IPR000210 BTB/POZ-like
IPR011333 BTB/POZ fold
IPR011705 BTB/Kelch-associated
IPR012983 PHR
IPR013069 BTB/POZ
PFAM PF07707
PF08005
PF00651
PRINTS
PIRSF
SMART SM00225
SM00875
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58545
PhosphoSite PhosphoSite-P58545
TrEMBL Q8CHC1
UniProt Splice Variant
Entrez Gene 228662
UniGene Mm.470620
RefSeq NP_663509
MGI ID
MGI Symbol Btbd3
OMIM
CCDS CCDS16798
HPRD
IMGT
EMBL AB093275 AK161924 AL772205 AL935129 BC018174 BC062968 CH466519
GenPept AAH18174 AAH62968 BAC41459 BAE36636 EDL28399

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca