InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acsm1

Summary

InnateDB Protein

IDBP-208024.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acsm1

Protein Name

acyl-CoA synthetase medium-chain family member 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036140

InnateDB Gene

IDBG-208022 (Acsm1)

Protein Structure

UniProt Annotation

Function

Functions as GTP-dependent lipoate-activating enzyme that generates the substrate for lipoyltransferase (By similarity). Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). {ECO:0000250, ECO:0000269PubMed:11470804}.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:11470804}.

Disease Associations

Tissue Specificity

Highly expressed in liver and kidney. {ECO:0000269PubMed:11470804}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003996	acyl-CoA ligase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0015645	fatty acid ligase activity
GO:0046872	metal ion binding
GO:0047760	butyrate-CoA ligase activity