InnateDB Protein
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IDBP-208045.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Bhlha15
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Protein Name
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basic helix-loop-helix family, member a15
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Synonyms
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1810009C13Rik; Bhlhb8; MIST-1; Mist1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000055493
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InnateDB Gene
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IDBG-208043 (Bhlha15)
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Protein Structure
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Function |
Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3'. {ECO:0000269PubMed:15003629, ECO:0000269PubMed:15665001, ECO:0000269PubMed:9482738}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in pancreatic tissue only in acinar cells. There is a complete absence of expression in intra- or interlobular pancreatic ducts and in all islet cells. {ECO:0000269PubMed:11696558}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000977
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RNA polymerase II regulatory region sequence-specific DNA binding
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GO:0001228
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RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0042803
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protein homodimerization activity
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GO:0046983
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protein dimerization activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:891976
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QYC3
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PhosphoSite |
PhosphoSite-Q9QYC3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
17341
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UniGene |
Mm.386767
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RefSeq |
NP_034930
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MGI ID |
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MGI Symbol |
Bhlha15
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OMIM |
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CCDS |
CCDS19847
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HPRD |
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IMGT |
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EMBL |
AF049660
AF091858
AK020643
BC011486
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GenPept |
AAD51766
AAF17706
AAH11486
BAB32160
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