Version 5.4
Mus musculus Protein: Cpsf3l
Summary
InnateDB Protein IDBP-208048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cpsf3l
Protein Name cleavage and polyadenylation specific factor 3-like
Synonyms 2410006F12Rik; AU044035;
Species Mus musculus
Ensembl Protein ENSMUSP00000030901
InnateDB Gene IDBG-208046 (Cpsf3l)
Protein Structure
UniProt Annotation
Function Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0008150 biological_process
GO:0016180 snRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0032039 integrator complex
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID MGI:1919207
InterPro IPR001279 Beta-lactamase-like
IPR011108 RNA-metabolising metallo-beta-lactamase
IPR022712 Beta-Casp domain
PFAM PF00753
PF07521
PF10996
PRINTS
PIRSF
SMART SM00849
SM01027
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CWS4
PhosphoSite PhosphoSite-Q9CWS4
TrEMBL
UniProt Splice Variant
Entrez Gene 71957
UniGene Mm.475640
RefSeq NP_082296
MGI ID
MGI Symbol Cpsf3l
OMIM
CCDS CCDS19048
HPRD
IMGT
EMBL AK010425 AK090206 AK150436 AK152740 AK167607 AK172533 BC008240 BC011155
GenPept AAH08240 AAH11155 BAB26928 BAC41135 BAE29558 BAE31460 BAE39661 BAE43054

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca