InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tgfb2

Summary

InnateDB Protein

IDBP-208113.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tgfb2

Protein Name

transforming growth factor, beta 2

Synonyms

BB105277; Tgf-beta2; Tgfb-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043849

InnateDB Gene

IDBG-208111 (Tgfb2)

Protein Structure

UniProt Annotation

Function

TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0005102	receptor binding
GO:0005114	type II transforming growth factor beta receptor binding
GO:0005160	transforming growth factor beta receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0000902	cell morphogenesis
GO:0001501	skeletal system development
GO:0001502	cartilage condensation
GO:0001568	blood vessel development
GO:0001654	eye development
GO:0001666	response to hypoxia
GO:0001837	epithelial to mesenchymal transition
GO:0001942	hair follicle development
GO:0001974	blood vessel remodeling
GO:0003007	heart morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003214	cardiac left ventricle morphogenesis
GO:0003215	cardiac right ventricle morphogenesis
GO:0006468	protein phosphorylation
GO:0007050	cell cycle arrest
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007184	SMAD protein import into nucleus
GO:0007411	axon guidance
GO:0007435	salivary gland morphogenesis
GO:0007507	heart development
GO:0008219	cell death
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008347	glial cell migration
GO:0009611	response to wounding
GO:0010002	cardioblast differentiation
GO:0010628	positive regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010693	negative regulation of alkaline phosphatase activity
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010936	negative regulation of macrophage cytokine production
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016049	cell growth
GO:0016477	cell migration
GO:0022601	menstrual cycle phase
GO:0023014	signal transduction by phosphorylation
GO:0030097	hemopoiesis
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030307	positive regulation of cell growth
GO:0030308	negative regulation of cell growth
GO:0030593	neutrophil chemotaxis
GO:0031069	hair follicle morphogenesis
GO:0032147	activation of protein kinase activity
GO:0032570	response to progesterone
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0032909	regulation of transforming growth factor beta2 production
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0040007	growth
GO:0042060	wound healing
GO:0042416	dopamine biosynthetic process
GO:0042493	response to drug
GO:0042637	catagen
GO:0042981	regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0045216	cell-cell junction organization
GO:0045617	negative regulation of keratinocyte differentiation
GO:0045726	positive regulation of integrin biosynthetic process
GO:0045778	positive regulation of ossification
GO:0045787	positive regulation of cell cycle
GO:0045823	positive regulation of heart contraction
GO:0048103	somatic stem cell division
GO:0048566	embryonic digestive tract development
GO:0048663	neuron fate commitment
GO:0048666	neuron development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050714	positive regulation of protein secretion
GO:0050778	positive regulation of immune response
GO:0051781	positive regulation of cell division
GO:0051795	positive regulation of catagen
GO:0051891	positive regulation of cardioblast differentiation
GO:0060038	cardiac muscle cell proliferation
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060325	face morphogenesis
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0060412	ventricular septum morphogenesis
GO:0070237	positive regulation of activation-induced cell death of T cells
GO:0097191	extrinsic apoptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005768	endosome
GO:0030424	axon
GO:0031012	extracellular matrix
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:98726

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR003940 Transforming growth factor, beta 2
IPR015618 Transforming growth factor beta 3
IPR016319 Transforming growth factor-beta
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR01425
PR01426
PR01423

PIRSF

PIRSF001787

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References