InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dgke

Summary

InnateDB Protein

IDBP-208185.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dgke

Protein Name

diacylglycerol kinase, epsilon

Synonyms

C87606; DAGK6; DGK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000285

InnateDB Gene

IDBG-208183 (Dgke)

Protein Structure

UniProt Annotation

Function

Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in platelets. {ECO:0000269PubMed:23542698}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016310	phosphorylation
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1889276

InterPro

IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding

PFAM

PF00609
PF00781
PF00130

PRINTS

PIRSF

SMART

SM00045
SM00046
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R1C6