InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmem100

Summary

InnateDB Protein

IDBP-208306.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmem100

Protein Name

transmembrane protein 100

Synonyms

1810057C19Rik; AV011897;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090464

InnateDB Gene

IDBG-208304 (Tmem100)

Protein Structure

UniProt Annotation

Function

Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. {ECO:0000269PubMed:22783020}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:23485812}; Multi-pass membrane protein {ECO:0000269PubMed:23485812}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000269PubMed:23485812}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in neurons as well as nerve fiber bundles connecting ganglia and fibers innervating muscle layer of the gastric body, jejunum, and proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral nervous system (at protein level). Expressed strongly in lung, weakly in brain, heart and muscle. Expressed in enteric neurons and vascular tissue in the muscularis propria of the gastrointestinal tract. {ECO:0000269PubMed:22783020, ECO:0000269PubMed:23485812}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0001525	angiogenesis
GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0007219	Notch signaling pathway
GO:0030509	BMP signaling pathway
GO:0043491	protein kinase B signaling
GO:0045603	positive regulation of endothelial cell differentiation
GO:0060842	arterial endothelial cell differentiation
GO:0071773	cellular response to BMP stimulus
GO:2001214	positive regulation of vasculogenesis

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm