Mus musculus Protein: Crym
Summary
InnateDB Protein IDBP-208346.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crym
Protein Name crystallin, mu
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000033198
InnateDB Gene IDBG-208344 (Crym)
Protein Structure
UniProt Annotation
Function Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0042562 hormone binding
GO:0042803 protein homodimerization activity
GO:0047127 thiomorpholine-carboxylate dehydrogenase activity
GO:0050661 NADP binding
GO:0070324 thyroid hormone binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007605 sensory perception of sound
GO:0042403 thyroid hormone metabolic process
GO:0055114 oxidation-reduction process
GO:0070327 thyroid hormone transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:102675
InterPro IPR003462 Ornithine cyclodeaminase/mu-crystallin
IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
PFAM PF02423
PF01488
PRINTS
PIRSF PIRSF001439
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O54983
PhosphoSite PhosphoSite-O54983
TrEMBL Q3UPX0
UniProt Splice Variant
Entrez Gene 12971
UniGene Mm.9114
RefSeq NP_057878
MGI ID 4BVA
MGI Symbol Crym
OMIM
CCDS CCDS21794
HPRD
IMGT
EMBL AF039391 AK138422 AK143116 AK163781 BC045159 CH466531
GenPept AAB94770 AAH45159 BAE23654 BAE25274 BAE37489 EDL17205