InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cpsf4

Summary

InnateDB Protein

IDBP-208580.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cpsf4

Protein Name

cleavage and polyadenylation specific factor 4

Synonyms

30kDa; C79664;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069243

InnateDB Gene

IDBG-208578 (Cpsf4)

Protein Structure

UniProt Annotation

Function

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding