Version 5.4
Mus musculus Protein: Spag9
Summary
InnateDB Protein IDBP-208596.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spag9
Protein Name sperm associated antigen 9
Synonyms 3110018C07Rik; 4733401I23Rik; 4831406C20Rik; AW552012; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4; syd1;
Species Mus musculus
Ensembl Protein ENSMUSP00000075115
InnateDB Gene IDBG-208586 (Spag9)
Protein Structure
UniProt Annotation
Function The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. {ECO:0000269PubMed:12391307, ECO:0000269PubMed:15767678}.
Subcellular Localization Cytoplasm. Cytoplasm, perinuclear region. Note=Perinuclear distribution in response to stress signals such as UV radiation.
Disease Associations
Tissue Specificity Isoform 6 is highly expressed in brain, kidney, liver, heart. {ECO:0000269PubMed:15767678}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008432 JUN kinase binding
GO:0019894 kinesin binding
GO:0048273 mitogen-activated protein kinase p38 binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0007257 activation of JUN kinase activity
GO:0030335 positive regulation of cell migration
GO:0042147 retrograde transport, endosome to Golgi
GO:0043410 positive regulation of MAPK cascade
GO:0045666 positive regulation of neuron differentiation
GO:0051146 striated muscle cell differentiation
GO:0051260 protein homooligomerization
GO:0090074 negative regulation of protein homodimerization activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1918084
InterPro IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58A65
PhosphoSite PhosphoSite-Q58A65
TrEMBL
UniProt Splice Variant
Entrez Gene 70834
UniGene Mm.479010
RefSeq NP_001020600
MGI ID
MGI Symbol Spag9
OMIM
CCDS CCDS56797
HPRD
IMGT
EMBL AB047782 AF327451 AK147431 AK147537 AK172961 AL662838 AY823270 BC060100 BC094670
GenPept AAH60100 AAH94670 AAN61564 AAX19462 BAD32239 BAD93176 BAE27907 BAE27980 CAI35367 CAI35375 CAI35376

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca