InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rasl11a

Summary

InnateDB Protein

IDBP-208923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasl11a

Protein Name

RAS-like, family 11, member A

Synonyms

1110065D03Rik; AI852031;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031646

InnateDB Gene

IDBG-208921 (Rasl11a)

Protein Structure

UniProt Annotation

Function

Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription. {ECO:0000269PubMed:20168301}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:20168301}. Note=Associates with rDNA transcription unit throughout the cell cycle.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0045943	positive regulation of transcription from RNA polymerase I promoter

Cellular Component

GO:0005622	intracellular
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1916145

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF08477

PRINTS

PR00449

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt