InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Flt3

Summary

InnateDB Protein

IDBP-209047.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Flt3

Protein Name

FMS-like tyrosine kinase 3

Synonyms

B230315G04; CD135; Flk-2; Flk2; Flt-3; Ly72; wmfl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039041

InnateDB Gene

IDBG-209045 (Flt3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0032403	protein complex binding
GO:0035259	glucocorticoid receptor binding
GO:0043548	phosphatidylinositol 3-kinase binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002318	myeloid progenitor cell differentiation
GO:0002320	lymphoid progenitor cell differentiation
GO:0002328	pro-B cell differentiation
GO:0002572	pro-T cell differentiation
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0010243	response to organonitrogen compound
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030097	hemopoiesis
GO:0030098	lymphocyte differentiation
GO:0031100	organ regeneration
GO:0045578	negative regulation of B cell differentiation
GO:0046777	protein autophosphorylation
GO:0071385	cellular response to glucocorticoid stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:95559

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013151 Immunoglobulin
IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00047

PRINTS

PR00109

PIRSF

PIRSF000615
PIRSF500947

SMART

SM00220
SM00409
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References