InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cst3

Summary

InnateDB Protein

IDBP-209153.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cst3

Protein Name

cystatin C

Synonyms

CysC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028938

InnateDB Gene

IDBG-209151 (Cst3)

Protein Structure

UniProt Annotation

Function

As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0001654	eye development
GO:0001666	response to hypoxia
GO:0001775	cell activation
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0007420	brain development
GO:0007431	salivary gland development
GO:0007566	embryo implantation
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0009636	response to toxic substance
GO:0009743	response to carbohydrate
GO:0010035	response to inorganic substance
GO:0010951	negative regulation of endopeptidase activity
GO:0014070	response to organic cyclic compound
GO:0031667	response to nutrient levels
GO:0032355	response to estradiol
GO:0034599	cellular response to oxidative stress
GO:0042493	response to drug
GO:0042747	circadian sleep/wake cycle, REM sleep
GO:0043067	regulation of programmed cell death
GO:0045740	positive regulation of DNA replication
GO:0048678	response to axon injury
GO:0060009	Sertoli cell development
GO:0060548	negative regulation of cell death
GO:0070301	cellular response to hydrogen peroxide

Cellular Component

GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0030424	axon
GO:0031965	nuclear membrane
GO:0031982	vesicle
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043292	contractile fiber
GO:0048471	perinuclear region of cytoplasm