InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc7a1

Summary

InnateDB Protein

IDBP-209271.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc7a1

Protein Name

solute carrier family 7 (cationic amino acid transporter, y+ system), member 1

Synonyms

4831426K01Rik; AI447493; Atrc-1; Atrc1; Cat1; mCAT-1; Rec-1; Rev-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046714

InnateDB Gene

IDBG-209269 (Slc7a1)

Protein Structure

UniProt Annotation

Function

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor. {ECO:0000269PubMed:1652100}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highest levels found in the testis and bone marrow. Not found in the liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015171	amino acid transmembrane transporter activity
GO:0015181	arginine transmembrane transporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006810	transport
GO:0006865	amino acid transport
GO:0015809	arginine transport
GO:0055085	transmembrane transport