InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acss1

Summary

InnateDB Protein

IDBP-209316.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acss1

Protein Name

acyl-CoA synthetase short-chain family member 1

Synonyms

1110032O15Rik; Acas2; Acas2l; AceCS2; AI788978;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028944

InnateDB Gene

IDBG-209314 (Acss1)

Protein Structure

UniProt Annotation

Function

Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions. Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2). {ECO:0000269PubMed:11150295, ECO:0000269PubMed:16790548, ECO:0000269PubMed:19187775}.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:11150295}.

Disease Associations

Tissue Specificity

Highly expressed in heart, testis, kidney, skeletal muscle, lung and spleen. Detected at low levels in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003987	acetate-CoA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016208	AMP binding

Biological Process

GO:0006085	acetyl-CoA biosynthetic process
GO:0008152	metabolic process
GO:0019413	acetate biosynthetic process
GO:0019427	acetyl-CoA biosynthetic process from acetate
GO:0019542	propionate biosynthetic process