Version 5.4
Mus musculus Protein: Dlx4
Summary
InnateDB Protein IDBP-209528.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dlx4
Protein Name distal-less homeobox 4
Synonyms Dlx-4; Dlx7;
Species Mus musculus
Ensembl Protein ENSMUSP00000021241
InnateDB Gene IDBG-209526 (Dlx4)
Protein Structure
UniProt Annotation
Function May play a role in determining the production of hemoglobin S. May act as a repressor.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
Disease Associations
Tissue Specificity Branchial arches, molar and incisor teeth and limbs.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:94904
InterPro IPR000047 Helix-turn-helix motif
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
PFAM PF00046
PRINTS PR00031
PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70436
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 13394
UniGene Mm.439766
RefSeq NP_031893
MGI ID
MGI Symbol Dlx4
OMIM
CCDS CCDS25273
HPRD
IMGT
EMBL AF452637 AK145123 AL645850 BC106967 U73329
GenPept AAC52995 AAI06968 AAL99501 BAE26247 CAI24123

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca