Version 5.4
| Mus musculus Protein: Rspo4 | |||||
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| Summary | |||||
| InnateDB Protein | IDBP-209569.6 | ||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
| Gene Symbol | Rspo4 | ||||
| Protein Name | R-spondin family, member 4 | ||||
| Synonyms | |||||
| Species | Mus musculus | ||||
| Ensembl Protein | ENSMUSP00000041578 | ||||
| InnateDB Gene | IDBG-209567 (Rspo4) | ||||
| Protein Structure |
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| UniProt Annotation | |||||
| Function | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. {ECO:0000269PubMed:21693646}. | ||||
| Subcellular Localization | Secreted {ECO:0000250}. | ||||
| Disease Associations | |||||
| Tissue Specificity | |||||
| Comments | |||||
| Interactions | |||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||
| PDB ID | MGI:1924467 | ||||
| InterPro |
IPR000884
Thrombospondin, type 1 repeat IPR006212 Furin-like repeat IPR009030 Insulin-like growth factor binding protein, N-terminal |
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| PFAM |
PF00090
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| PRINTS | |||||
| PIRSF | |||||
| SMART |
SM00209
SM00261 |
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| TIGRFAMs | |||||
| Post-translational Modifications | |||||
| Modification | |||||
| Cross-References | |||||
| SwissProt | Q8BJ73 | ||||
| PhosphoSite | PhosphoSite- | ||||
| TrEMBL | Q0P5Y9 | ||||
| UniProt Splice Variant | |||||
| Entrez Gene | 228770 | ||||
| UniGene | Mm.159868 | ||||
| RefSeq | NP_001035779 | ||||
| MGI ID | |||||
| MGI Symbol | Rspo4 | ||||
| OMIM | |||||
| CCDS | CCDS38272 | ||||
| HPRD | |||||
| IMGT | |||||
| EMBL | AK020904 BC048707 BC116367 | ||||
| GenPept | AAH48707 AAI16368 BAC25643 | ||||