InnateDB Protein
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IDBP-209586.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Angpt4
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Protein Name
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angiopoietin 4
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Synonyms
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Agpt4; Ang3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000028955
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InnateDB Gene
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IDBG-209584 (Angpt4)
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Protein Structure
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Function |
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. {ECO:0000269PubMed:15284220}.
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Subcellular Localization |
Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Widely expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005172
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vascular endothelial growth factor receptor binding
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GO:0030297
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transmembrane receptor protein tyrosine kinase activator activity
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GO:0030971
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receptor tyrosine kinase binding
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Biological Process |
GO:0001525
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angiogenesis
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GO:0007171
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activation of transmembrane receptor protein tyrosine kinase activity
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GO:0007492
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endoderm development
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GO:0010595
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positive regulation of endothelial cell migration
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GO:0016525
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negative regulation of angiogenesis
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GO:0043066
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negative regulation of apoptotic process
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GO:0043536
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positive regulation of blood vessel endothelial cell migration
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GO:0043537
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negative regulation of blood vessel endothelial cell migration
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GO:0045766
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positive regulation of angiogenesis
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GO:0048014
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Tie signaling pathway
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GO:0050731
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positive regulation of peptidyl-tyrosine phosphorylation
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GO:0071456
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cellular response to hypoxia
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Cellular Component |
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PDB ID |
MGI:1336887
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InterPro |
IPR002181
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
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PFAM |
PF00147
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PRINTS |
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PIRSF |
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SMART |
SM00186
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WVH6
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PhosphoSite |
PhosphoSite-Q9WVH6
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TrEMBL |
Q3V0P7
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UniProt Splice Variant |
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Entrez Gene |
11602
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UniGene |
Mm.189536
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RefSeq |
NP_033771
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MGI ID |
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MGI Symbol |
Angpt4
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OMIM |
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CCDS |
CCDS16874
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HPRD |
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IMGT |
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EMBL |
AF113707
AK132988
BC129966
CH466551
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GenPept |
AAD21586
AAI29967
BAE21457
EDL05940
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