InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tcf15

Summary

InnateDB Protein

IDBP-209619.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcf15

Protein Name

transcription factor 15

Synonyms

bHLH-EC2; Meso1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086511

InnateDB Gene

IDBG-209617 (Tcf15)

Protein Structure

UniProt Annotation

Function

May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Expressed in heart and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001756	somitogenesis
GO:0003016	respiratory system process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007517	muscle organ development
GO:0009952	anterior/posterior pattern specification
GO:0016265	death
GO:0036342	post-anal tail morphogenesis
GO:0042755	eating behavior
GO:0043583	ear development
GO:0043588	skin development
GO:0045198	establishment of epithelial cell apical/basal polarity
GO:0048339	paraxial mesoderm development
GO:0048644	muscle organ morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0050884	neuromuscular process controlling posture
GO:0060231	mesenchymal to epithelial transition
GO:1901311	regulation of gene expression involved in extracellular matrix organization

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:104664

InterPro

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

PFAM

PF00010

PRINTS

PIRSF

SMART

SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q60756

PhosphoSite

PhosphoSite-Q60756

TrEMBL

UniProt Splice Variant

Entrez Gene

21407

UniGene

RefSeq

NP_033354

MGI ID

MGI Symbol

Tcf15

OMIM

CCDS

CCDS16878

HPRD

IMGT

EMBL

BC027533 U18658 U20164

GenPept

AAA86825 AAB48215 AAH27533