InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Skap1

Summary

InnateDB Protein

IDBP-209954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Skap1

Protein Name

src family associated phosphoprotein 1

Synonyms

1700091G21Rik; Scap1; Skap-55;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098090

InnateDB Gene

IDBG-209950 (Skap1)

Protein Structure

UniProt Annotation

Function

Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0032403	protein complex binding
GO:0042169	SH2 domain binding