InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHX29

Summary

InnateDB Protein

IDBP-21046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX29

Protein Name

DEAH (Asp-Glu-Ala-His) box polypeptide 29

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000251636

InnateDB Gene

IDBG-21044 (DHX29)

Protein Structure

UniProt Annotation

Function

ATP-binding RNA helicase involved in translation initiation. Part of the 43S preinitiation complex that is required for efficient initiation on mammalian mRNAs with structured 5'- UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. {ECO:0000269PubMed:19109895, ECO:0000269PubMed:23706745}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003743	translation initiation factor activity
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0043024	ribosomal small subunit binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006413	translational initiation

Cellular Component

GO:0005739	mitochondrion
GO:0016282	eukaryotic 43S preinitiation complex

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR007502 Helicase-associated domain
IPR011545 DEAD/DEAH box helicase domain
IPR011709 Domain of unknown function DUF1605
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04408
PF00270
PF07717

PRINTS

PIRSF

SMART

SM00490
SM00847
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7Z478