InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map1lc3a

Summary

InnateDB Protein

IDBP-210555.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map1lc3a

Protein Name

microtubule-associated protein 1 light chain 3 alpha

Synonyms

1010001H21Rik; 4922501H04Rik; LC3; LC3a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029128

InnateDB Gene

IDBG-210553 (Map1lc3a)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=LC3-II binds to the autophagic membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	95 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008429	phosphatidylethanolamine binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000422	mitochondrion degradation
GO:0006914	autophagy

Cellular Component

GO:0000421	autophagic vacuole membrane
GO:0005737	cytoplasm
GO:0005770	late endosome
GO:0005776	autophagic vacuole
GO:0005829	cytosol
GO:0005874	microtubule
GO:0031090	organelle membrane
GO:0031410	cytoplasmic vesicle