Version 5.4
Mus musculus Protein: Rgs10
Summary
InnateDB Protein IDBP-210656.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rgs10
Protein Name regulator of G-protein signalling 10
Synonyms 2310010N19Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000033133
InnateDB Gene IDBG-210654 (Rgs10)
Protein Structure
UniProt Annotation
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)- alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043679 axon terminus
Protein Structure and Domains
PDB ID MGI:1915115
InterPro IPR000342 Regulator of G protein signalling domain
IPR016137 Regulator of G protein signalling superfamily
PFAM PF00615
PRINTS PR01301
PIRSF
SMART SM00315
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQE5
PhosphoSite PhosphoSite-Q9CQE5
TrEMBL Q32MD7
UniProt Splice Variant
Entrez Gene 67865
UniGene Mm.18635
RefSeq NP_080694
MGI ID
MGI Symbol Rgs10
OMIM
CCDS CCDS21896
HPRD
IMGT
EMBL AK009283 AK009686 AK017314 AK088009 BC109178 CH466531
GenPept AAI09179 BAB26193 BAB26440 BAB30688 BAC40091 EDL17646

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca