Version 5.4
Mus musculus Protein: Mcmbp
Summary
InnateDB Protein IDBP-210704.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mcmbp
Protein Name MCM (minichromosome maintenance deficient) binding protein
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000062843
InnateDB Gene IDBG-210702 (Mcmbp)
Protein Structure
UniProt Annotation
Function Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0000084 mitotic S phase
GO:0006261 DNA-dependent DNA replication
GO:0007062 sister chromatid cohesion
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0042555 MCM complex
Protein Structure and Domains
PDB ID MGI:1920977
InterPro IPR019140 Mini-chromosome maintenance complex-binding protein
PFAM PF09739
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R3C0
PhosphoSite PhosphoSite-Q8R3C0
TrEMBL
UniProt Splice Variant
Entrez Gene 210711
UniGene Mm.58882
RefSeq NP_666067
MGI ID
MGI Symbol Mcmbp
OMIM
CCDS CCDS40153
HPRD
IMGT
EMBL AC122767 AC136741 BC025641 BC038342
GenPept AAH25641 AAH38342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca