InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gdf5

Summary

InnateDB Protein

IDBP-210736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gdf5

Protein Name

growth differentiation factor 5

Synonyms

BMP-14; bp; brp; Cdmp-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048079

InnateDB Gene

IDBG-210734 (Gdf5)

Protein Structure

UniProt Annotation

Function

Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B (By similarity). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion (By similarity). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. {ECO:0000250, ECO:0000269PubMed:24076600}.

Subcellular Localization

Secreted {ECO:0000250}. Cell membrane {ECO:0000250}.

Disease Associations

Note=Defects in Gdf5 are the cause of brachypodism (bp) which alters the length and numbers of bones in the limbs but spares the axial skeleton.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0002062	chondrocyte differentiation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0030326	embryonic limb morphogenesis
GO:0032332	positive regulation of chondrocyte differentiation
GO:0035136	forelimb morphogenesis
GO:0035137	hindlimb morphogenesis
GO:0040007	growth
GO:0040014	regulation of multicellular organism growth
GO:0043524	negative regulation of neuron apoptotic process
GO:0045666	positive regulation of neuron differentiation
GO:0050680	negative regulation of epithelial cell proliferation
GO:2001054	negative regulation of mesenchymal cell apoptotic process