Version 5.4
Mus musculus Protein: Krt12
Summary
InnateDB Protein IDBP-211036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Krt12
Protein Name keratin 12
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000017741
InnateDB Gene IDBG-211034 (Krt12)
Protein Structure
UniProt Annotation
Function May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity. {ECO:0000269PubMed:7508359, ECO:0000269PubMed:8977471}.
Subcellular Localization
Disease Associations
Tissue Specificity Cornea specific. Associated mainly with all layers of the central corneal epithelium and also found in the suprabasal limbal epithelium. {ECO:0000269PubMed:7508359}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
Cellular Component
GO:0005882 intermediate filament
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:96687
InterPro IPR001664 Intermediate filament protein
IPR002957 Keratin, type I
IPR009053 Prefoldin
PFAM PF00038
PRINTS PR01248
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Z4YJD9
UniProt Splice Variant
Entrez Gene 268482
UniGene Mm.436651
RefSeq NP_034791
MGI ID
MGI Symbol Krt12
OMIM
CCDS CCDS36306
HPRD
IMGT
EMBL AL591165
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca